Impact of levothyroxine therapy on lipid profile in overt hypothyroidism: a retrospective cohort study

Hypothyroidism is closely associated with dyslipidemia, contributing to cardiovascular morbidity and mortality. The aim of the current study was to assess levothyroxine impact on lipid profile parameters [total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C)], in subjects with overt hypothyroidism (OH) and hyperlipidemia and to determine whether the impact varies by levothyroxine dosage.